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Certain areas hurt more than others. For instance I've heard that ankles hurt more than certain other areas. I got my first tattoo on the calf and it wasn't too bad.

My friend puked when she got hers on her wrist so I guess puking is okay.

Generally the artists will let you take a break if needed. My artist took three breaks which was also SUPER helpful for me. I also told him when I started to feel sick during the three-hour mark and he was very accommodating with that, letting me lay down and getting me water and such. So just tell them how you're feeling and they'll try to help

Bring snacks, or at least orange juice to keep your sugar up.

As far as moisturizing goes, ask your artist what they recommend. Mine told me to use A&D ointment on it for about a week about 3x a day and then start applying a scentless lotion.